NFL Week 6 picks, predictions, schedule, odds, fantasy suggestions

The Week 6 NFL schedule for the 2025 season brings some intriguing matchups.

After a 206-yard dashing recreation final week, Panthers RB Rico Dowdle will look to have a repeat efficiency in opposition to the Cowboys, his former crew. The Bucs will host the 49ers for a showdown between 4-1 groups. And the Lions go to the Chiefs' Arrowhead Stadium for the second time in three seasons.

We've got you lined with all the things you might want to know. Our NFL Nation reporters take you contained in the locker room with the very best factor they heard this week, and ESPN Analysis supplies a key stat to know and a betting nugget for every contest. Plus, analytics author Seth Walder makes a daring prediction for every matchup, and fantasy analyst Eric Moody shares fantasy soccer intel. We even have Soccer Energy Index (FPI) matchup high quality scores (out of 100) and recreation projections, and three analysts — Pamela Maldonado, Moody and Walder — give us last rating picks for each recreation.

Let's get into the complete Week 6 slate, which culminates with a “Monday Evening Soccer” doubleheader between the Payments and Falcons (on ESPN) and the Bears at Commanders (on ABC). (Sport instances are Sunday until in any other case famous.)

Soar to a matchup:
NYJ-DEN | LAR-BAL | SEA-JAX
ARI-IND | LAC-MIA | DAL-CAR
CLE-PIT | NE-NO | TEN-LV
SF-TB | CIN-GB | DET-KC
BUF-ATL | CHI-WSH

Thursday: PHI-NYG
Bye: MIN, HOU

9:30 a.m. ET | NFL Community | Matchup score: 44.9/100
ESPN BET: DEN -6.5 (43.5 O/U)

What we're listening to on the Jets: DT Quinnen Williams stated it greatest: “We're 0-5 and the protection has been the issue, the explanation why we're 0-5.” The Jets have zero takeaways and solely three sacks prior to now 4 video games. Go rush was an emphasis in follow this week, however a breakout in opposition to the Broncos will not be straightforward. They've allowed solely 5 sacks this season. — Wealthy Cimini

What we're listening to on the Broncos: The Broncos left for London simply hours after their win over Philadelphia, the signature win of coach Sean Payton's Denver tenure. Payton stated he left behind any notion that taking part in the Jets at Tottenham Stadium is any type of entice recreation for the 3-2 Broncos. “Every week it is the power to refocus on the following problem,” Payton stated. “… These guys perceive in our league, it is completely different than faculty. We're not getting an opportunity to play a I-AA or FCS faculty. These are all skilled groups, and we'll deal with it that manner.” — Jeff Legwold

Stat to know: Broncos QB Bo Nix was held to solely 60 passing yards in final season's 10-9 win over the Jets, the one time in his profession that he has been held beneath 130 passing yards. — ESPN Analysis

Daring prediction: Jets RB Breece Corridor might be held to 1 or fewer receptions. The Jets throw to their operating again 26% of the time, fourth most of any crew. However the Broncos' man-heavy protection permits a decrease fee of targets to operating backs (12%) than every other crew. — Walder

Accidents: Jets | Broncos

Fantasy nugget: Jets QB Justin Fields completed with 25.9 fantasy factors in Week 5. Nevertheless, he faces a Broncos protection that has allowed the third-fewest fantasy factors and dashing yards per recreation to QBs this season. Fantasy managers ought to think about pivoting to a streamer this week. See Week 6 rankings. — Moody

Betting nugget: Groups favored by no less than 4 factors in worldwide video games are 16-9 ATS and 19-6 outright. Learn extra. — ESPN Analysis

Maldonado's choose: Broncos 31, Jets 6
Moody's choose: Broncos 30, Jets 17
Walder's choose: Broncos 22, Jets 12
FPI prediction: DEN, 70.8% (by a median of 8.3 factors)

Matchup must-reads: Jets vow to maintain battling regardless of being NFL's lone winless crew … How the Broncos, Elway constructed an NFL basic supervisor tree

1 p.m. ET | Fox | Matchup score: 74.3/100
ESPN BET: LAR -7.5 (44.5 O/U)

What we're listening to on the Rams: By way of 5 weeks, Rams QB Matthew Stafford leads the league with 1,503 passing yards and is simply 50 yards away from passing Dan Marino (61,361) for the ninth-most passing yards in NFL historical past. The Ravens have allowed 177 factors this season, essentially the most over a five-game span in franchise historical past, based on ESPN Analysis. Baltimore can be permitting a median of 262.6 passing yards per recreation, the second-worst mark within the NFL. — Sarah Barshop

What we're listening to on the Ravens: RB Derrick Henry has been held to 50 dashing yards or much less in 4 straight video games, which matches the worst rut of his profession. It is vital to get Henry again on observe for the Ravens, who're 10-1 when Henry produces greater than 90 yards dashing. However the Rams, who've the NFL's No. 10 run protection, have allowed just one operating again to realize over 90 yards dashing this season (Tony Pollard). “We've got the very best [running] again within the recreation,” Ravens C Tyler Linderbaum stated, “so now we have to discover a solution to be higher.” — Jamison Hensley

Stat to know: The Ravens had been outscored by 17-plus factors in every of their previous two video games. They've by no means misplaced three straight video games by no less than three scores in franchise historical past. — ESPN Analysis

Daring prediction: The Rams will full a number of 40-plus-yard passes. By way of 5 weeks, the Rams have the best air yards per try within the league at 8.5, and Baltimore's protection is permitting 8.0 air yards per goal (fourth most). Though I feel the Ravens' protection will finally determine it out, the very best guess for now could be that it'll proceed to battle within the quick time period. — Walder

Accidents: Rams | Ravens

Fantasy nugget: The Ravens' protection has been decimated by accidents, which has led Baltimore to permit the second-most fantasy factors per recreation to QBs. Stafford has scored no less than 25 fantasy factors in back-to-back video games, and with Puka Nacua and Davante Adams as his prime two receivers, he ought to ship one other distinctive efficiency in opposition to Baltimore. See Week 6 rankings. — Moody

Betting nugget: The Rams are 8-1 ATS as highway favorites since 2022 and 5-0 ATS because the begin of final season. Learn extra. — ESPN Analysis

Maldonado's choose: Rams 23, Ravens 20
Moody's choose: Rams 31, Ravens 16
Walder's choose: Rams 30, Ravens 14
FPI prediction: LAR, 58.7% (by a median of three.3 factors)

Matchup must-reads: After a number of missed kicks, the stress is on Rams kicking unit … Bateman says 1-4 Ravens ‘deserve all of the criticism' … The AFC North QB panorama shouldn't be what it was to begin the season: What is going on on?

1 p.m. ET | Fox | Matchup score: 57.5/100
ESPN BET: SEA -1.5 (47.5 O/U)

What we're listening to on the Seahawks: The Seahawks' protection acquired lit up in Week 5 largely as a consequence of its lack of ability to get stress on Bucs QB Baker Mayfield, who was hit solely as soon as on 38 dropbacks. Up subsequent is Jacksonville's Trevor Lawrence, who has been sacked solely six instances in 5 video games. Coach Mike Macdonald credited the Jaguars' skill to remain on schedule and keep away from pure dropback conditions as one issue, together with Lawrence making fast selections. “The receivers are getting open, and he is throwing the ball on time,” Macdonald stated. “He is throwing it precisely, and so they're defending him.” — Brady Henderson

What we're listening to on the Jaguars: The Jaguars' offensive power is their floor recreation (fifth within the NFL at 137 dashing yards per recreation) and so they'll face their hardest take a look at of the season in opposition to Seattle, which has the third-best run protection within the league (83 yards per recreation). Working again Travis Etienne Jr. described the Seahawks' entrance as recreation wreckers and stated they current “a number of turmoil.” The Jaguars possible will not have middle Robert Hainsey (hamstring), so rookie seventh-round choose Jonah Monheim will fill in — a tricky activity for his first begin. — Michael DiRocco

Stat to know: The Jaguars have 14 takeaways this season, essentially the most within the NFL. — ESPN Analysis

Daring prediction: The Seahawks unleash QB Sam Darnold and have him throw 40 cross makes an attempt. Sure, even in opposition to a Jaguars protection that ranks third in EPA per dropback allowed. The Seahawks have been a lot extra environment friendly passing than operating this season (.28 EPA per play to minus-0.07) and must lean extra on that a part of their recreation. Plus, the Jaguars have a brand new CB in Greg Newsome II, who would possibly nonetheless be getting used to the protection. — Walder

Accidents: Seahawks | Jaguars

Fantasy nugget: In opposition to the Chiefs, WR/CB Travis Hunter had a season excessive in offensive snaps and likewise posted a profession excessive in receiving yards for the second straight recreation. The Seahawks' secondary is a middle-of-the-pack unit and simply allowed Bucs rookie WR Emeka Egbuka to attain 31.3 fantasy factors in opposition to them. Hunter might have a breakout efficiency. See Week 6 rankings. — Moody

Betting nugget: The Seahawks have received eight straight highway video games outright. They're 9-1 beneath Macdonald over the previous two seasons. Learn extra. — ESPN Analysis

Maldonado's choose: Seahawks 17, Jaguars 16
Moody's choose: Jaguars 27, Seahawks 24
Walder's choose: Seahawks 30, Jaguars 24
FPI prediction: JAX, 50.2% (by a median of 0.1 factors)

Matchup must-reads: Seahawks QB Darnold proved potential in Week 5 loss … Jaguars LB Lloyd is flourishing in new protection … Jaguars get Newsome, ship Campbell to Browns

1 p.m. ET | Fox | Matchup score: 58.1/100
ESPN BET: IND -7.5 (46.5 O/U)

What we're listening to on the Cardinals: WR Marvin Harrison Jr. has lastly discovered a rhythm over the previous two weeks, and it has resulted in a major bounce in explosive performs. In Week 4 and Week 5 mixed — each losses — Harrison was liable for seven explosive performs, in contrast with simply two within the first three video games. This week is one other alternative for Harrison so as to add to his whole, because the Colts have given up 23 explosive passes this season — 12 prior to now two video games. “I imply it helps to catch explosives,” Harrison stated. “I feel each video games, that definitely helps and then you definately type of get a rhythm from there.” — Josh Weinfuss

What we're listening to on the Colts: This might be an fascinating matchup as a result of the Colts are No. 2 in factors per recreation (32.6) and the Cardinals are permitting solely 19.2 factors per recreation. Can the Colts handle to seek out options to a protection that has restricted the 49ers and Seahawks in latest weeks? It's going to be one of many greatest checks for QB Daniel Jones and the Colts, who've been creating weekly fireworks. Notably, the Cardinals haven't allowed a 100-yard dashing efficiency, whereas Colts RB Jonathan Taylor is averaging 96 yards per recreation. — Stephen Holder

Stat to know: Jones leads the NFL in QBR exterior the pocket when pressured and on third down. He's second in Whole QBR this season (79.6), behind Seahawks QB Sam Darnold. — ESPN Analysis

Daring prediction: The Colts will common beneath 4.0 yards per carry. They're dealing with a Cardinals protection that has allowed the bottom EPA per designed carry this season, and that would put an actual pressure on the run-heavy Colts offense. — Walder

Accidents: Cardinals | Colts

Fantasy nugget: Harrison has amassed 15 targets and 32.4 fantasy factors over his previous two video games, and Indianapolis' protection has allowed the second-most receptions and fifth-most fantasy factors per recreation to broad receivers. Harrison might be motivated to shine on the highway in opposition to his Corridor of Fame father's former crew. See Week 6 rankings. — Moody

Betting nugget: Cardinals QB Kyler Murray is 27-13-1 ATS on the highway in his profession, together with 22-7-1 ATS as a highway underdog. He's 18-6-1 ATS when getting no less than three factors on the highway. Learn extra. — ESPN Analysis

Maldonado's choose: Colts 26, Cardinals 24
Moody's choose: Colts 28, Cardinals 23
Walder's choose: Cardinals 19, Colts 16
FPI prediction: IND, 65.3% (by a median of 5.9 factors)

Matchup must-reads: Cardinals' Harrison displays on ‘particular recreation' vs. dad's Colts … Colts signal LB Pratt two days after launch by Raiders … Cardinals QB Murray not training as a consequence of foot harm … Colts signal Badgley to interchange injured Shrader

1 p.m. ET | CBS | Matchup score: 46.7/100
ESPN BET: LAC -3.5 (43.5 O/U)

What we're listening to on the Chargers: Earlier than buying and selling for Ravens edge rusher Odafe Oweh, the Chargers had just one participant ranked within the prime 125 in stress fee (LB Tuli Tuipulotu, twelfth). Oweh, who ranks thirty third in pressures, is about to make his debut for Los Angeles on Sunday. “He is loads like Khalil Mack. Direct rusher, however has pace, has depth, has skill to set the sting,” coach Jim Harbaugh stated. “Been an excellent, productive younger participant, within the prime of his profession.” — Kris Rhim

What we're listening to on the Dolphins: Sunday marks the fourth matchup between QBs Justin Herbert and Tua Tagovailoa as NFL starters, with Tagovailoa's Dolphins main the sequence 2-1. The 2 quarterbacks had been taken with consecutive picks in 2020, however Tagovailoa stated he would not talk a lot with the opposite quarterbacks in his draft class. “I do know everybody desires to do the comparisons with all of the dudes that had been in my draft class,” Tagovailoa stated, “however all you are able to do is be pleased for the fellows, the place they're at of their lifetime of soccer and need the very best for them. That is all I might need to do and hope the identical in return.” — Marcel Louis-Jacques

Stat to know: Since Mike McDaniel took over as coach of the Dolphins in 2022, they're 3-14 in opposition to groups that entered the sport with successful data. — ESPN Analysis

Daring prediction: Chargers RBs Hassan Haskins and Kimani Vidal will mix for 150 or extra dashing yards. The Chargers are producing 3.0 yards earlier than contact per carry, fifth greatest within the NFL, whereas the Dolphins' protection is permitting 3.2 yards earlier than contact per carry, second most within the NFL. — Walder

Accidents: Chargers | Dolphins

Fantasy nugget: One development bolstered in Week 5 is that you will need to begin operating backs in opposition to the Dolphins. Carolina's Rico Dowdle scored 32.4 fantasy factors, and with Chargers RB Omarion Hampton touchdown on IR with an ankle harm, Haskins — anticipated to deal with early-down and goal-line work — could possibly be the following to profit. The Dolphins' protection has allowed the fifth-most fantasy factors per recreation to operating backs. See Week 6 rankings. — Moody

Betting nugget: Tagovailoa is 6-3 ATS and 5-4 outright in his profession as a house underdog. Learn extra. — ESPN Analysis

Maldonado's choose: Chargers 35, Dolphins 13
Moody's choose: Chargers 26, Dolphins 24
Walder's choose: Chargers 31, Dolphins 13
FPI prediction: LAC, 60.2% (by a median of three.9 factors)

Matchup must-reads: Three huge questions dealing with the Chargers after shedding two straight … Dolphins unconcerned as Tua restricted by hand, hip … McDaniel: Dolphins proprietor ‘actually annoyed'

1 p.m. ET | Fox | Matchup score: 43.5/100
ESPN BET: DAL -3.5 (49.5 O/U)

What we're listening to on the Cowboys: Panthers RB Rico Dowdle stated his former crew goes to must “buckle up” on Sunday. It is a remark that the Cowboys are very effectively conscious of. Though the Dallas run protection has improved, it ranks twenty third within the league and is permitting 4.4 yards per carry. “It will be a battle within the trenches for certain,” DT Kenny Clark stated. “Trenches going to win this recreation.” — Todd Archer

What we're listening to on the Panthers: Buckle up. That has been the mantra since Dowdle stated the Cowboys higher be prepared for a bodily recreation after dashing for 206 yards in opposition to Miami. The identical could possibly be true for Carolina, because it faces the league's No. 1 offense with an bettering protection that also struggles to stress the quarterback and canopy tight ends. — David Newton

Stat to know: The Cowboys are the one crew within the NFL this season scoring and permitting 30.0 factors per recreation. They're the primary crew to do this by 5 video games of the season because the 2021 Chiefs. — ESPN Analysis

Daring prediction: Whoever begins at operating again — be it Dowdle or Chuba Hubbard — will catch 5 or extra passes, tying Hubbard's season excessive (and two greater than Dowdle's). The Cowboys are operating 83% zone protection, the best fee of any crew in its first 5 video games since our protection knowledge begins in 2017. And operating backs catch passes at a a lot greater fee in opposition to zone than man. — Walder

Accidents: Cowboys | Panthers

Fantasy nugget: WR Tetairoa McMillan has seen eight or extra targets in each recreation this season. He is additionally QB Bryce Younger's prime vertical risk, main Carolina with seven targets of 20-plus yards. The Cowboys' protection has allowed essentially the most fantasy factors per recreation to broad receivers. See Week 6 rankings. — Moody

Betting nugget: Cowboys QB Dak Prescott is 0-4 ATS in his previous 4 video games as a favourite, however he's 49-36-2 ATS as a favourite all through his profession. Learn extra. — ESPN Analysis

Maldonado's choose: Cowboys 21, Panthers 14
Moody's choose: Cowboys 31, Panthers 23
Walder's choose: Cowboys 34, Panthers 24
FPI prediction: DAL, 61.3% (by a median of 4.3 factors)

Matchup must-reads: Cowboys TE Ferguson's historic tempo isn't any fluke … QB Younger, Panthers look to construct on comeback victory … Harm-riddled Cowboys lean on unsung heroes to beat Jets … Panthers RBs Dowdle, Hubbard prepared for Cowboys protection

1 p.m. ET | CBS | Matchup score: 37.6/100
ESPN BET: PIT -5.5 (38.5 O/U)

What we're listening to on the Browns: The Browns turned to rookie QB Dillon Gabriel final week, nevertheless it wasn't sufficient to show round an offense that hasn't eclipsed 17 factors in 10 straight video games. This week's preparation has been extra in line with the crew at its follow facility in Berea, Ohio, as a substitute of abroad in London. It ought to assist Gabriel forward of his second begin, nevertheless it's nonetheless a frightening activity in Pittsburgh, the place Cleveland hasn't received a regular-season recreation since 2003. “It is the sport of soccer, it is the previous. Does not actually matter, what's in entrance is what issues,” coach Kevin Stefanski stated. — Daniel Oyefusi

What we're listening to on the Steelers: LT Broderick Jones is loads conscious of the duty he is dealing with in Browns cross rusher Myles Garrett. However the Steelers might need discovered a key to serving to Jones sluggish Garrett with their use of versatile lineman Spencer Anderson. A 2023 seventh-round choose, Anderson performed 19 snaps (35%) in opposition to the Vikings, up from simply 4 (8.2%) in opposition to the Patriots every week earlier. QB Aaron Rodgers was sacked simply twice in these two video games mixed, an enchancment from taking seven sacks within the first two weeks of the season. The Browns, in the meantime, are fifth within the league with 14 sacks by 5 video games. Additionally, regulate TE Darnell Washington as an additional blocker within the Steelers' run recreation. — Brooke Pryor

Stat to know: The Steelers have received eight straight video games following the bye going again to 2017, the second-longest energetic win streak within the NFL. — ESPN Analysis

Daring prediction: Steelers edge rusher Nick Herbig will file a number of sacks. Herbig has performed far too effectively to take off the sphere (his 39% cross rush win fee leads all gamers) even with Alex Highsmith doubtlessly again in motion. Herbig now ought to face backup OT KT Leveston, who ranks 58th out of 64 tackles in cross block win fee (80%). — Walder

Accidents: Browns | Steelers

Fantasy nugget: RB Quinshon Judkins has recorded 19 or extra touches in three consecutive video games, scoring no less than 14 fantasy factors in every. The Browns' offensive line should not have any hassle creating holes for him, particularly in opposition to a Steelers defensive entrance that ranks twenty third in run cease win fee and offers up the Eleventh-most dashing yards per recreation to operating backs. See Week 6 rankings. — Moody

Betting nugget: The Browns are 0-7 ATS of their previous seven highway video games, the longest energetic highway ATS shedding streak within the NFL. Learn extra. — ESPN Analysis

Maldonado's choose: Steelers 27, Browns 13
Moody's choose: Steelers 27, Browns 17
Walder's choose: Steelers 20, Browns 13
FPI prediction: PIT, 65.0% (by a median of 5.3 factors)

Matchup must-reads: What to make of the Browns' offense after QB Gabriel's first begin … Why the return of S Elliott means a lot to Pittsburgh's protection … How does QB Flacco commerce impression Gabriel, Sanders? … The AFC North QB panorama shouldn't be what it was to begin the season: What is going on on?

1 p.m. ET | CBS | Matchup score: 32.7/100
ESPN BET: NE -3.5 (45.5 O/U)

What we're listening to on the Patriots: The psychological problem of resetting after an upset road win was highlighted by WR Stefon Diggs, who stated: “To be sincere, it is likely to be an even bigger take a look at than final week, so far as having success and having the ability to replicate that course of and do it another time. … We've got to go in there with the suitable mindset.” Among the many areas the Patriots have focused for enchancment are higher communication within the low crimson zone and the dashing assault (averaging 98.0 yards per recreation, ranked twenty seventh within the NFL). — Mike Reiss

What we're listening to on the Saints: DE Chase Younger could possibly be on his manner again after lacking the primary 5 video games with a calf harm. Coach Kellen Moore stated “there's clearly optimism” for Younger to play on Sunday. Moore stated they're going to proceed to see how the harm responds day-after-day. The opposite harm to look at is RB Alvin Kamara, who was restricted in Wednesday's follow with an ankle harm. If Kamara can not play or is restricted, anticipate Kendre Miller to take nearly all of the load. — Katherine Terrell

Stat to know: Saints WR Chris Olave's 54 targets are the second most in NFL this season behind the Rams' Puka Nacua (63). — ESPN Analysis

Daring prediction: Diggs will proceed his scorching streak and file 80-plus receiving yards in opposition to the Saints. By way of 5 weeks, Diggs ranks second in ESPN's open score. — Walder

Accidents: Patriots | Saints

Fantasy nugget: Patriots RB TreVeyon Henderson has had solely two video games this season with 10 or extra touches. New England has break up carries between Rhamondre Stevenson, Antonio Gibson and Henderson up to now, however with Gibson out for the season as a consequence of a torn ACL and Stevenson battling ball safety (eight fumbles), the stage is about for Henderson to shine in opposition to a Saints protection that has allowed the Tenth-most fantasy factors per recreation to operating backs. See Week 6 rankings. — Moody

Betting nugget: The Saints are 7-14 ATS as house underdogs since 2020 (0-3 ATS previous three). QB Spencer Rattler is 1-10 outright and 3-8 ATS in his profession as a starter. Learn extra. — ESPN Analysis

Maldonado's choose: Patriots 26, Saints 23
Moody's choose: Patriots 23, Saints 19
Walder's choose: Patriots 27, Saints 20
FPI prediction: NE, 59.8% (by a median of 4.2 factors)

Matchup must-reads: Patriots lose RB Gibson to torn ACL, sources say … Why Saints' Moore sees extra involvement forward for Hill, Moreau

4:05 p.m. ET | Fox | Matchup score: 16.0/100
ESPN BET: LV -3.5 (40.5 O/U)

What we're listening to on the Titans: Coach Brian Callahan left final week's win impressed with QB Cam Ward's fourth-quarter passing: 13-of-18 for 193 yards. Callahan stated it was a giant second and step for Ward to take, however he'd wish to extrapolate that success over the complete course of a recreation. Ward ought to get the chance to stack one other good day in opposition to a Raiders cross protection that is permitting 222.6 yards per recreation — ranked twenty second — if the Titans can decelerate edge rusher Maxx Crosby. — Turron Davenport

What we're listening to on the Raiders: If the Raiders need an opportunity to snap their four-game shedding streak on Sunday, they must do a greater job at capitalizing within the crimson zone. Las Vegas was 0-for-4 within the crimson zone in opposition to the Colts final week. The crew is thirty first within the league in crimson zone conversion fee at 35.7%. “Proper now, I feel we're most likely one of many worst groups within the crimson zone,” RB Ashton Jeanty stated. “… All people look within the mirror and see how we will get higher.” — Ryan McFadden

Stat to know: Jeanty leads all rookies in dashing makes an attempt (82) and dashing yards (349) this season. — ESPN Analysis

Daring prediction: Crosby will file a number of sacks. He is going in opposition to Ward, who's taking sacks at a large 10% clip. My sack mannequin provides Crosby a 19% likelihood to file no less than 2.0 sacks this week — the best of any participant in Week 6. — Walder

Accidents: Titans | Raiders

Fantasy nugget: Titans WR Calvin Ridley set season highs in Week 5 in targets (10), receptions (5), receiving yards (131) and fantasy factors (18.1). As he continues to construct chemistry with Ward, Ridley now faces a Raiders protection that has allowed the fourth-most fantasy factors per recreation to wideouts. See Week 6 rankings. — Moody

Betting nugget: The Titans haven't lined back-to-back video games since Weeks 1-2 of 2023. Learn extra. — ESPN Analysis

Maldonado's choose: Raiders 23, Titans 20
Moody's choose: Raiders 20, Titans 17
Walder's choose: Raiders 23, Titans 9
FPI prediction: LV, 64.6% (by a median of 5.7 factors)

Matchup must-reads: QB Ward's ‘poise' a giant a part of Titans' epic comeback, future

4:25 p.m. ET | CBS | Matchup score: 68.0/100
ESPN BET: TB -3.5 (47.5 O/U)

What we're listening to on the 49ers: At 4-1 with every of these video games determined by 5 factors or fewer, the 49ers have discovered a solution to win tight video games late. So, too, have the Buccaneers, who have not performed a recreation determined by greater than six factors and received 4 of them. It is made it tough to inform simply how good these groups are, however Sunday's matchup ought to supply the very best glimpse but into the trajectory of the season for either side. It is an concept that's not misplaced on LB Fred Warner. “These are the moments you dream of,” he stated. “Greatest on greatest, an away recreation, they flexed the sport for all the explanations that we're talking of … It will be an incredible problem for us.” — Nick Wagoner

What we're listening to on the Buccaneers: Final season, the Bucs misplaced 23-20 to the Niners, unable to cease a last-minute game-winning drive for a 44-yard area purpose. Now the Bucs have 4 victories by three factors or fewer in 5 video games. The interception from LB Lavonte David final week within the last minute was the play they didn't have final 12 months. Security Tykee Smith stated, “The most important studying lesson I might say is us having the ability to put the fireplace out when it was time.” — Jenna Laine

Stat to know: The 49ers have 4 straight wins in opposition to the Buccaneers relationship again to 2019, their longest energetic win streak in opposition to any opponent. — ESPN Analysis

Daring prediction: Warner will lead the league in Week 6 mixed tackles. The Buccaneers are favored and still have a minus-9% cross fee over expectation this season, fourth lowest within the NFL. That ought to result in a number of sort out alternatives for the linebacker. — Walder

Accidents: 49ers | Buccaneers

Fantasy nugget: The Buccaneers' defensive entrance ranks Eleventh in run cease win fee (30.8%), however fantasy managers should not fear about Niners RB Christian McCaffrey. Tampa Bay has allowed the third-most receiving yards per recreation to operating backs. McCaffrey's 387 receiving yards are 117 greater than every other RB this season. See Week 6 rankings. — Moody

Betting nugget: Bucs QB Baker Mayfield is 18-31-1 ATS in his profession as a favourite (8-8 ATS with Tampa Bay). Learn extra. — ESPN Analysis

Maldonado's choose: Buccaneers 24, 49ers 22
Moody's choose: Buccaneers 33, 49ers 30
Walder's choose: Buccaneers 27, 49ers 23
FPI prediction: TB, 58.3% (by a median of three.2 factors)

Matchup must-reads: The 49ers' run recreation is dormant, however McCaffrey shouldn't be … Notion of Bucs' QB Mayfield shifting amid MVP-type run

4:25 p.m. ET | CBS | Matchup score: 63.3/100
ESPN BET: GB -14.5 (44.5 O/U)

What we're listening to on the Bengals: Welcome to Cincinnati, QB Joe Flacco. Since stepping into city on Tuesday night time, Flacco has been cramming the playbook so as to face the Packers for the second time in 4 weeks. Cleveland's Week 3 win at house over Inexperienced Bay was his lone victory in 4 begins this season. Coach Zac Taylor stated that though it is no less than good that Flacco has already confronted the Packers this season, it will likely be completely different since crowd noise at Lambeau Discipline might be added to the listing of challenges dealing with him and the offense. — Ben Child

What we're listening to on the Packers: The Packers have struggled to get their operating recreation going, however Josh Jacobs is not overly involved or stunned, though they ranked 18th in dashing yards per recreation (114.5) by their first 4 video games. “For some purpose my profession's simply all the time been like that,” stated Jacobs, who ranks Eleventh in particular person dashing yards per recreation (66.5). “Prefer it's all the time been like a month of soccer the place you get used to being hit, getting used to straining and going in opposition to different good gamers to actually perceive wish to get into that movement virtually of what it takes and the best way to be higher.” — Rob Demovsky

Stat to know: If/when Flacco begins, he can be the fourth QB to begin for 2 groups inside the similar division in the identical season because the 1970 merger. — ESPN Analysis

Daring prediction: The Packers will win by 20-plus factors. I do not suppose Flacco — who at the moment is sporting a 27.6 QBR that's even worse than Jake Browning's — might be a lot assist. And even after Inexperienced Bay's latest semi-skid, I nonetheless imagine it is without doubt one of the highest groups within the league. FPI agrees, at the moment rating the Packers third. — Walder

Accidents: Bengals | Packers

Fantasy nugget: Jacobs faces a Bengals protection that has allowed essentially the most fantasy factors per recreation to RBs. The Packers are double-digit favorites, suggesting they need to be taking part in with a lead, which bodes effectively for Jacobs. He has averaged 20.3 touches and 17.4 fantasy factors per recreation since arriving in Inexperienced Bay. See Week 6 rankings. — Moody

Betting nugget: The Bengals are 1-4 ATS this season and 0-3 ATS on the highway. Learn extra. — ESPN Analysis

Maldonado's choose: Packers 17, Bengals 13
Moody's choose: Packers 34, Bengals 20
Walder's choose: Packers 34, Bengals 13
FPI prediction: GB, 80.6% (by a median of 13.2 factors)

Matchup must-reads: Bengals say Flacco commerce provides crew hope for this season … When will Packers' WR Watson return from ACL harm? … What Doubs' scorching begin means for his future with Packers

8:20 p.m. ET | NBC | Matchup score: 89.3/100
ESPN BET: KC -1.5 (52.5 O/U)

What we're listening to on the Lions: The Lions return to face the Chiefs for the primary time since they marched into Arrowhead Stadium for a 21-20 season-opening win in 2023. Coach Dan Campbell remembers that prime-time expertise being helpful to constructing their basis, as they went toe-to-toe with the then-reigning Tremendous Bowl champion and got here out on prime utilizing complementary soccer. “That was huge. I felt like that type of kicked our season off. Guys actually believed we might go on the market and win and performed their tails off,” Campbell stated. — Eric Woodyard

What we're listening to on the Chiefs: The Chiefs might as soon as once more face an in depth recreation. The offense for every crew is performing effectively, which suggests the Chiefs will hope to alter their development of beginning the season 0-3 in one-score video games. “We're simply not making successful performs in sure moments,” QB Patrick Mahomes stated. “On this league, it is going to come right down to one-score video games. That is what coach [Andy] Reid preaches proper after we begin off coaching camp each single 12 months. It is about who executes at the next degree, and we've not accomplished that as a crew all through these first 5 weeks.” — Nate Taylor

Stat to know: Together with the playoffs, Jared Goff is the one QB whom Mahomes has began in opposition to a number of instances and hasn't overwhelmed. — ESPN Analysis

Daring prediction: There might be no less than a 24-pass try disparity between Goff and Mahomes. The Chiefs rank first in cross fee over expectation, and the Lions rank thirty first. If Detroit will get out forward, Mahomes might throw a ton of passes, and Goff would possibly barely throw any. — Walder

Accidents: Lions | Chiefs

Fantasy nugget: The Lions' defensive entrance is hard, permitting the seventh-fewest fantasy factors per recreation to RBs. It's going to be exhausting for managers to belief Kareem Hunt and Isiah Pacheco of their lineups. Kansas Metropolis would possibly lean extra on Mahomes and its receivers, and the Lions have allowed the seventh-most fantasy factors per recreation to wideouts. See Week 6 rankings. — Moody

Betting nugget: Mahomes is 17-7-1 ATS when he's not no less than a three-point favourite. Learn extra. — ESPN Analysis

Maldonado's choose: Chiefs 27, Lions 21
Moody's choose: Lions 34, Chiefs 24
Walder's choose: Lions 30, Chiefs 23
FPI prediction: KC, 54.8% (by a median of 1.9 factors)

Matchup must-reads: Lions CB Arnold relieved harm will not finish season … Mahomes irked after Monday night time loss: ‘Let a recreation slip away' … Inside Hutchinson's fascinating return to dominance

7:15 p.m. ET | ESPN | Matchup score: 59.3/100
ESPN BET: BUF -4.5 (49.5 O/U)

What we're listening to on the Payments: Buffalo's offense has an additional day to organize after the crew's first loss, which was additionally the primary time it failed to attain 30 factors this season. One goal is lowering the turnovers (three vs. New England) in opposition to a Falcons crew that has six takeaways on the season (tied for Eleventh most). However an vital a part of the offense that could possibly be a problem in opposition to Atlanta is the large performs. The Payments are second within the NFL with 37 explosive performs (rushes of 10-plus yards and completions of 20-plus yards), however the Falcons have allowed simply 14 explosive performs this season, second fewest within the NFL. — Alaina Getzenberg

What we're listening to on the Falcons: Atlanta's protection has been glorious in opposition to the cross up to now. It has allowed the fewest passing yards per recreation (108) — 46 yards per recreation fewer than every other crew — and opposing groups have the seventh-worst EPA per dropback (minus-0.09) in opposition to the Falcons and the sixth-worst completion share over anticipated (minus-3.1%). Nevertheless, the Falcons haven't confronted a QB like Josh Allen, whom coach Raheem Morris known as “an issue all over the place.” — Marc Raimondi

Stat to know: Falcons RB Bijan Robinson has 5 straight video games with 100 yards from the road of scrimmage relationship again to final season. That is tied with 49ers RB Christian McCaffrey for the longest energetic streak within the NFL. — ESPN Analysis

Daring prediction: The Falcons will generate a number of 30-plus-yard positive aspects on performs the place they use movement on the snap. They use movement on the snap 53% of the time (second within the NFL), and the Payments are permitting 0.23 EPA per play vs. movement on the snap, third most within the NFL this season. — Walder

Accidents: Payments | Falcons

Fantasy nugget: The Payments' protection has allowed the sixth-fewest fantasy factors per recreation to WRs this season. Drake London did have 10 targets and a season-high 25 fantasy factors in Week 4, however this is not a good matchup. Buffalo's protection might be seeking to bounce again from a disappointing loss and will make issues robust for second-year QB Michael Penix Jr. See Week 6 rankings. — Moody

Betting nugget: The Payments are 0-3 ATS of their previous three video games, their longest ATS shedding streak since Weeks 5-10 of 2023 (six straight). Learn extra. — ESPN Analysis

Maldonado's choose: Payments 34, Falcons 31
Moody's choose: Payments 35, Falcons 21
Walder's choose: Payments 30, Falcons 20
FPI prediction: BUF, 61.0% (by a median of 4.6 factors)

Matchup must-reads: Payments' Coleman benched for disciplinary causes … Second-year DTs bolster improved Falcons protection … Payments final unbeaten to fall: ‘We simply performed sloppy'

8:15 p.m. ET | ABC | Matchup score: 60.6/100
ESPN BET: WSH -4.5 (50.5 O/U)

What we're listening to on the Bears: Misplaced within the chaos of Washington beating Chicago on a tipped Hail Mary cross final season was QB Caleb Williams main what would've been a game-winning drive within the two-minute drill. That is an space the place Williams shines essentially the most, and the final impression of him and the offense earlier than the bye was him marching his crew down the sphere in Las Vegas to take the lead again. “[Williams] lives in that world,” WR DJ Moore stated. “If he might get in that world and play off-schedule and two-minute mode, it is robust. We're simply taking part in off of him and going on the market and taking part in yard soccer with him.” — Courtney Cronin

What we're listening to on the Commanders: The pregame storyline will contain QB Jayden Daniels' Hail Mary cross that beat Chicago final season, nevertheless it'll be Washington's run recreation that would make the distinction this time. Washington leads the NFL with 156.4 yards dashing per recreation and 5.9 yards per carry. In the meantime, Chicago ranks thirty first in dashing yards allowed per recreation (164.5) and final in common per carry (6.1). The Commanders use a assorted rush assault, however rookie Jacory Croskey-Merritt has began to emerge with a career-best 111 yards in Week 5. “He simply has to maintain working to turn into a whole again, however since day one when [he] touches the ball, he does good issues with it,” offensive coordinator Kliff Kingsbury stated. — John Keim

Stat to know: That is the primary beginning QB matchup in “Monday Evening Soccer” historical past between the highest two picks from the identical draft class. (Williams was taken No. 1 by the Bears, and Daniels was taken No. 2 by the Commanders.) — ESPN Analysis

Daring prediction: Croskey-Merritt will file a 40-plus-yard run. The Commanders rank first in yards after contact per carry (2.8), and the Bears rank final in yards after contact allowed per carry (3.2). — Walder

Accidents: Bears | Commanders

Fantasy nugget: The Commanders' backfield has been a dreaded three-man committee up to now this season, nevertheless it was encouraging to see Croskey-Merritt end Week 5 with 16 touches and 27.0 fantasy factors, thanks to 2 dashing touchdowns. Now, the rookie faces a Bears defensive entrance that ranks close to the underside of the league in run cease win fee (27.3%). See Week 6 rankings. — Moody

Betting nugget: The Bears are 8-15 ATS of their previous 23 video games as a highway underdog. That is their thirty first consecutive highway recreation as an underdog, the longest energetic streak within the NFL. Learn extra. — ESPN Analysis

Maldonado's choose: Commanders 23, Bears 14
Moody's choose: Commanders 31, Bears 28
Walder's choose: Bears 40, Commanders 28
FPI prediction: WSH, 65.3% (by a median of 5.9 factors)

Matchup must-reads: ‘Fail Mary' backlash nonetheless hurts Bears' Stevenson … ‘Composed' QB Daniels jolts Commanders in return from knee harm