NFL Week 1 picks, predictions, schedule, odds, fantasy ideas

The Week 1 NFL schedule for the 2025 season brings some thrilling matchups. The Chiefs will face the Chargers in Brazil, the Lions make a journey to Lambeau Subject and a must-see QB duel between Lamar Jackson and Josh Allen will probably be held in Buffalo.

We've got you lined with the whole lot you must know. Our NFL Nation reporters take you contained in the locker room with the perfect factor they heard this week, and ESPN Analysis offers a key stat to know and a betting nugget for every contest. Plus, analytics author Seth Walder makes a daring prediction for every matchup, and fantasy analyst Eric Moody shares fantasy soccer intel. We even have Soccer Energy Index (FPI) matchup high quality scores (out of 100) and recreation projections, and three analysts — Pamela Maldonado, Moody and Walder — give us remaining rating picks for each recreation.

Let's get into the total Week 1 slate, which culminates with the “Monday Evening Soccer” matchup between the Vikings and Bears on ESPN. (Sport occasions are Sunday until in any other case famous.)

Bounce to a matchup:
KC-LAC | NYG-WSH | CIN-CLE
TB-ATL | MIA-IND | PIT-NYJ
LV-NE | ARI-NO | CAR-JAX
SF-SEA | TEN-DEN | DET-GB
HOU-LAR | BAL-BUF | MIN-CHI

Thursday: DAL-PHI

Friday, 8 p.m. ET | YouTube | Matchup ranking: 75.1/100
ESPN BET: KC -3.5 (46.5 O/U)

What we're listening to on the Chiefs: The protection is raring to showcase its abilities towards its AFC West rival. Steve Spagnuolo, the longtime coordinator, by no means performed his beginning lineup within the preseason. “Lastly, to only go on the market and play a full recreation with one another and go hit any person apart from who we all the time hit goes to be very nice,” CB Trent McDuffie stated. “As you already know with Spags, I am form of doing a bunch of issues.” A lot of McDuffie's tasks will doubtless be following and protecting Ladd McConkey, the Chargers' prime receiver. “I actually like how he performs, his area separation out of the breaks and actually good routes. You may inform his timing with Justin Herbert over the course of [last] 12 months actually received higher. He'll be a very good problem for us on the again finish to see what we're about.” — Nate Taylor

What we're listening to on the Chargers: With a dashing offense that was beneath league common, receivers who struggled to get open (outdoors of McConkey) and manufacturing that incessantly sputtered in second halves, L.A.'s offense was its Achilles' heel in 2024. The Chargers spent the offseason retooling their offense, including working backs Najee Harris and Omarion Hampton, proper guard Mekhi Becton and large receiver Keenan Allen. With the brand new additions, the most important storyline heading into this season will probably be how offensive coordinator Greg Roman will increase productiveness in 2025. “On paper, I feel we're forward of the place we have been final 12 months this time,” Roman stated. “However we have got to go on the market and do it.” — Kris Rhim

Stat to know: Patrick Mahomes has an 82.6% win proportion in September, the second finest amongst beginning QBs since 1950 behind Roger Staubach's 84.6%. — ESPN Analysis

Daring prediction: Chiefs rookie LT Josh Simmons will report a 92% go block win fee in his NFL debut, solidly above the 89% common for a deal with. I am not that anxious in regards to the Chargers' go rush, and nearly as good as Khalil Mack has been over his profession, his PRWR has fallen off as he has aged. — Walder

Accidents: Chiefs | Chargers

Fantasy nugget: Xavier Worthy steps in as Mahomes' No. 1 receiver with Rashee Rice suspended for six video games. Worthy scored 19-plus fantasy factors in three of his remaining 4 regular-season video games final season and delivered an distinctive Tremendous Bowl efficiency. He ought to thrive towards a Chargers secondary that completed within the backside 10 in touchdowns allowed to large receivers in 2024. See Week 1 rankings. — Moody

Betting nugget: The Chargers had the perfect report towards the unfold (ATS) within the 2024 season, 13-4. Learn extra. — ESPN Analysis

Maldonado's choose: Chiefs 27, Chargers 24
Moody's choose: Chiefs 38, Chargers 23
Walder's choose: Chiefs 23, Chargers 20
FPI prediction: KC, 57% (by a median of two.9 factors)

Matchup must-reads: Kelce saddles up for potential final journey with Chiefs … How Jim Harbaugh has developed as Chargers coach

1 p.m. ET | Fox | Matchup ranking: 43.9/100
ESPN BET: WSH -6.5 (45.5 O/U)

What we're listening to on the Giants: The Giants misplaced rather a lot final season, together with each matchups with the Commanders by a complete of eight factors. That gave Washington quarterback Jayden Daniels bragging rights over his former faculty teammate and finest buddy, Giants large receiver Malik Nabers. It did not sit properly with Nabers, who's bored with all of the shedding. “I used to be like, ‘Sufficient is sufficient,'” Nabers stated. “‘I am coming to get you.'” He and the Giants have an opportunity at redemption in Week 1. — Jordan Raanan

What we're listening to on the Commanders: The Commanders know they're going through a entrance seven that, as offensive coordinator Kliff Kingsbury stated, is “as difficult as we'll face.” The Giants sacked Daniels 5 occasions of their first assembly however none within the second, whereas permitting a mixed 364 dashing yards within the two video games. “Lots of guys need to get their arms on them quick and that is the place they benefit from you. They need to rush the passer,” stated TE John Bates, one of many league's finest blockers, in regards to the Giants' defensive position. “I will not say they're probably the most want-to-be-physical kind guys, so it's important to have a base and have your ft beneath you and be poised.” — John Keim

Stat to know: Russell Wilson will make his two hundredth NFL begin in Week 1, changing into the sixteenth quarterback in NFL historical past to take action. Just one different QB has made his two hundredth begin in Week 1 of a season, and that participant additionally made his two hundredth begin in a Giants uniform: Eli Manning in 2017. — ESPN Analysis

Daring prediction: Giants WR Darius Slayton will report a 40-plus-yard reception, albeit in a shedding effort. Even in his later years, Wilson breaks out the occasional classic moon ball, and Slayton might properly be the beneficiary of such a go. — Walder

Accidents: Giants | Commanders

Fantasy nugget: The Commanders gave up 4.8 yards per stick with it 490 makes an attempt final season, the fourth-worst mark within the league, so Washington will doubtless load the field to sluggish Tyrone Tracy Jr. and the Giants' working recreation. That might open up vertical photographs for Nabers, even when CB Marshon Lattimore shadows him. Lattimore hasn't been as constant or wholesome lately, so Nabers' big-play capacity and the Giants' pass-first lean ought to place him for ample targets and a monster recreation. See Week 1 rankings. — Moody

Betting nugget: When the Commanders received each matchups towards the Giants in 2024 (going 2-0 ATS), it was their first time protecting in each conferences since 2012. Learn extra. — ESPN Analysis

Maldonado's choose: Commanders 23, Giants 17
Moody's choose: Commanders 21, Giants 20
Walder's choose: Commanders 24, Giants 17
FPI prediction: WSH, 68% (by a median of seven factors)

Matchup must-reads: Contained in the reimagined high-profile Giants QB room … Commanders embrace McLaurin's return to observe area … Giants' Nabers says again harm was ‘a minor factor'

1 p.m. ET | Fox | Matchup ranking: 43.8/100
ESPN BET: CIN -5.5 (48.5 O/U)

What we're listening to on the Bengals: No person wants to inform Bengals QB Joe Burrow that Browns DE Myles Garrett generally is a recreation wrecker. Garrett has sacked Burrow greater than some other participant within the NFL — 10 sacks in eight video games and a whopping 20 hits, per ESPN Analysis. Burrow stated it is crucial to know the place Garrett is on each snap and the place the new learn is in case Garrett blows up a play. “Generally he is again there earlier than you possibly can catch the ball, mainly, and it's important to get it out,” Burrow stated. — Ben Child

What we're listening to on the Browns: The Browns are going through a well-recognized divisional opponent, however coach Kevin Stefanski stated there is a little bit of thriller with new Bengals defensive coordinator Al Golden. “It's important to remember for the unknown,” Stefanski stated. “He can do something from a entrance standpoint, from a canopy standpoint.” Cleveland, although, will debut the most recent iteration of its offense with a renewed concentrate on working the ball. The Browns ranked twenty ninth in dashing yards per recreation final season (94.6) however are going through a Bengals protection that ranked twenty fifth in run cease win fee (28.9%). — Daniel Oyefusi

Stat to know: The Bengals have a 1-11 report in Weeks 1-2 since 2019 (when Zac Taylor grew to become coach), the worst within the league over that span. — ESPN Analysis

Daring prediction: Bengals RB Chase Brown will report a number of touchdowns. The Bengals ought to lean on Brown to rise up large towards the Joe Flacco-led Browns. And with 54 receptions final season, Brown confirmed he could make an influence within the passing recreation, too. — Walder

Accidents: Bengals | Browns

Fantasy nugget: David Njoku is about up for an enormous Week 1. The Bengals allowed the second-most fantasy factors to tight ends final season, and Njoku torched them in each matchups. Njoku is a powerful TE1 begin in what must be a high-scoring recreation. See Week 1 rankings. — Moody

Betting nugget: The Browns have six straight ATS losses as an underdog, the longest lively streak within the NFL. Learn extra. — ESPN Analysis

Maldonado's choose: Bengals 27, Browns 13
Moody's choose: Bengals 28, Browns 13
Walder's choose: Bengals 33, Browns 13
FPI prediction: CIN, 64.1%% (by a median of 6 factors)

Matchup must-reads: Bengals, Burrow able to ‘placed on a present' … How the Browns' pivotal offseason is shaping their future

1 p.m. ET | Fox | Matchup ranking: 43.6/100
ESPN BET: TB -1.5 (47.5 O/U)

What we're listening to on the Buccaneers: QB Baker Mayfield will face an enormous take a look at with out All-Professional LT Tristan Wirfs and two of his prime receivers in Chris Godwin Jr. (ankle) and Jalen McMillan (neck). TE Cade Otton's recreation standing can be in jeopardy with a groin harm. However Mayfield has been right here earlier than, having been with out, at one level, his prime three receivers final season. “When you're making an attempt to take a silver lining out of the accidents we had final 12 months, these guys needed to step up and play in an enormous method,” Mayfield stated, referring to Ryan Miller and Sterling Shepard. “Clearly, Tez [Johnson] and Mek [Emeka Egbuka] are new, however we belief them and we're trying ahead to them making performs for us.” Particularly with McMillan's harm, which occurred within the Bucs' second preseason recreation — that is the place Egbuka's capacity to be taught all of the receivers' roles on this offense goes to assist probably the most. — Jenna Laine

What we're listening to on the Falcons: When QB Michael Penix Jr. received right into a scuffle throughout a joint observe with the Titans final month, he famous in his information convention that he wasn't going to shrink back from a struggle as a result of “I am from Tampa.” In his first full season as starter, Penix will go up first towards his hometown group in Week 1, the division rival Buccaneers. The second-year quarterback stated he has managed to steal some followers away now that he is enjoying for Atlanta: “They're like, ‘Oh you are there now, so we received to switch over.'” — Marc Raimondi

Stat to know: The Falcons have received two straight and 4 of their previous 5 conferences towards the Bucs. — ESPN Analysis

Daring prediction: Egbuka will report a minimum of six receptions in his NFL debut. The thrill round Egbuka this preseason has been too sturdy to disregard, and he'll come out of the gates making performs straight away for a Buccaneers offense that wants him. — Walder

Accidents: Buccaneers | Falcons

Fantasy nugget: Bucs WR Mike Evans ought to see loads of targets towards a Falcons protection that allowed the fifth-most fantasy factors per recreation to WRs in 2024. Atlanta stays susceptible to outdoors receivers, and though it made personnel adjustments this offseason, the Falcons nonetheless battle to strain the quarterback, which places added stress on the secondary. Evans faces A.J. Terrell Jr., and of their Week 5 matchup final season he produced 23.2 fantasy factors. See Week 1 rankings. — Moody

Betting nugget: Mayfield is at minus-140 to throw over 1.5 landing passes; he had a number of passing touchdowns in 12 out of 17 begins in 2024. Learn extra. — ESPN Analysis

Maldonado's choose: Falcons 26, Buccaneers 24
Moody's choose: Buccaneers 33, Falcons 20
Walder's choose: Buccaneers 22, Falcons 20
FPI prediction: TB, 54.2% (by a median of two factors)

Matchup must-reads: Can Egbuka, others step up for injured WRs? … Mooney (shoulder) says he'll be a game-time name … Contained in the Falcons' competitors for proper deal with

1 p.m. ET | CBS | Matchup ranking: 36.9/100
ESPN BET: IND -1.5 (46.5 O/U)

What we're listening to on the Dolphins: After lacking practically the previous month with indirect and calf accidents, respectively, WR Tyreek Hill and RB De'Von Achane have returned to observe for the Dolphins and are anticipated to play. In regard to Miami's offensive cohesiveness having gone three weeks with out its two leaders in whole yards final season, coach Mike McDaniel stated that not solely have been Hill and Achane “on level” previous to their accidents, however he additionally “watched them within the classroom be stay motion individuals in a method that I feel might have been extra of a battle in years previous.” Translated: There isn't any concern that the Dolphins' stars will probably be acclimated come recreation day. — Marcel Louis-Jacques

What we're listening to on the Colts: The Colts have overhauled their protection with a brand new scheme that includes man-to-man protection, however the important thing participant, coaches and teammates say, is Laiatu Latu. The second-year edge rusher completed final season with simply two sacks, however the Colts are that includes him in 2025 in an effort to unlock his potential. “I feel he'll have a helluva season based mostly on what I've witnessed to this point,” coordinator Lou Anarumo stated. — Stephen Holder

Stat to know: That is Miami QB Tua Tagovailoa's first profession begin versus the Colts, the one AFC group (apart from the Dolphins) he has by no means confronted. — ESPN Analysis

Daring prediction: Colts QB Daniel Jones will rush for 40-plus yards. When Jones has been profitable, he has leaned on his legs, and I might count on coach Shane Steichen to attempt to maximize that a part of his recreation straight away. — Walder

Accidents: Dolphins | Colts

Fantasy nugget: Tyler Warren faces a Dolphins protection that allowed over 13 fantasy factors per recreation to tight ends final season and misplaced a number of key defensive contributors within the offseason. The rookie was chosen No. 14 after recording 1,233 receiving yards and 15 whole touchdowns in his remaining faculty season. Jones thrived concentrating on the center of the sector in 2024 and may leverage Warren's dimension and yards-after-catch capacity. See Week 1 rankings. — Moody

Betting nugget: The Colts are 2-12-1 ATS in Week 1 over the previous 15 seasons, the worst within the NFL over the span. Learn extra. — ESPN Analysis

Maldonado's choose: Dolphins 24, Colts 20
Moody's choose: Dolphins 31, Colts 21
Walder's choose: Colts 23, Dolphins 17
FPI prediction: IND, 50.5% (by a median of 0.6 factors)

Matchup must-reads: Tagovailoa says relationship with Hill ‘good' … Colts imagine in Jones' strategy at QB

1 p.m. ET | CBS | Matchup ranking: 37.8/100
ESPN BET: PIT -2.5 (37.5 O/U)

What we're listening to on the Steelers: Sure, the headline of this matchup is Aaron Rodgers' return to MetLife towards the Jets, however it's additionally an important measuring stick for a Steelers run protection that wilted down the stretch final season. The Steelers will face a stout RB tandem in Breece Corridor and Braelon Allen (whom coach Mike Tomlin in comparison with Detroit's Jahmyr Gibbs and David Montgomery) together with a well-recognized face in cellular QB Justin Fields — and so they'll achieve this with out first-round rookie DT Derrick Harmon (MCL sprain). However third-year lineman Keeanu Benton expressed confidence in his unit's enchancment from a season in the past. “We aren't all trying only for go rush and people large stats or sack stats,” he stated. “We're all the way down to get dirty.” — Brooke Pryor

What we're listening to on the Jets: Eight of the 11 starters on the Jets' protection confronted Rodgers final summer season in coaching camp. A small profit, maybe? Coach Aaron Glenn acknowledged their familiarity with Rodgers, who was minimize within the offseason, has “some worth.” It might assist them anticipate Rodgers' cadence/exhausting rely, which he makes use of as a weapon. Each Glenn and defensive coordinator Steve Wilks praised Rodgers' intelligence and expertise. However stated Glenn: “Bodily, all of us begin to wane in some unspecified time in the future as we become old.” — Wealthy Cimini

Stat to know: That is the primary season opener in NFL historical past between beginning quarterbacks who performed for the opposing group the earlier 12 months — in 2024, Fields was with the Steelers, and Rodgers was with the Jets. — ESPN Analysis

Daring prediction: These two groups will mix for 44 or fewer mixed go makes an attempt. Solely 5 video games final season had that few go makes an attempt between each groups, however I count on each of those squads to be significantly run heavy. If neither group pulls away, they every might stick to that recreation plan all through. — Walder

Accidents: Steelers | Jets

Fantasy nugget: The Steelers just lately gave RB Jaylen Warren an extension, and Tomlin made it clear he'll be No. 1 on the depth chart. Warren can be a powerful go catcher and excels in go safety, an vital talent with 41-year-old Rodgers underneath heart for the reason that veteran is not shy about utilizing his backs as receivers out of the backfield. That stated, Warren has by no means surpassed 15 dashing makes an attempt in a recreation in his profession, so hold that in thoughts when setting lineups. See Week 1 rankings. — Moody

Betting nugget: The underneath has hit in every of the previous six Steelers Week 1 video games, the longest lively streak within the NFL. Learn extra. — ESPN Analysis

Maldonado's choose: Jets 19, Steelers 17
Moody's choose: Jets 20, Steelers 17
Walder's choose: Steelers 19, Jets 16
FPI prediction: PIT, 58.8% (by a median of three.5 factors)

Matchup must-reads: Rodgers downplays going through Jets in Steelers' opener … Fields brings totally different dynamic than Rodgers

1 p.m. ET | CBS | Matchup ranking: 30.8/100
ESPN BET: NE -2.5 (44.5 O/U)

What we're listening to on the Raiders: Raiders rookie RB Ashton Jeanty understands he's greater than only a participant who runs defenders over. His shiftiness and talent to be elusive are different causes he's anticipated to have a big position towards the Patriots on Sunday. “I realized I in all probability must make extra guys miss,” Jeanty stated. “…I have been a reasonably bodily participant, and the eventualities I used to be put in, I form of needed to. However yeah, clearly, you need to choose and select your battles. The season is lengthy, and I need to be obtainable all through the entire season.” — Ryan McFadden

What we're listening to on the Patriots: First-year coach Mike Vrabel structured the observe script to incorporate a break adopted by two group intervals as a result of he wished to emphasize the significance of profitable the second half. Vrabel famous that 12 of the 16 Week 1 winners from 2024 outscored their opponents within the second half and that ties, partially, to conditioning constructed up over the course of coaching camp. “Conditioning makes cowards of us all,” veteran WR Mack Hollins stated. “Whenever you're drained, you may make an excuse for why you did not get a block, maintain on to the ball, go defend, make a deal with. However if you're in form, and you'll see your opponent off form, it is a significantly better feeling.” — Mike Reiss

Stat to know: The Raiders are looking for their third straight win over New England, after having misplaced the earlier six conferences from 2005 to 2020. — ESPN Analysis

Daring prediction: Raiders edge rusher Malcolm Koonce will report a sack. Is Patriots rookie LT Will Campbell — whom Koonce seems set to principally face — prepared for the professionals straight away? We're about to seek out out. — Walder

Accidents: Raiders | Patriots

Fantasy nugget: In 11 begins from Week 6 to 17 final season, Patriots QB Drake Maye posted 2,254 passing yards, 15 TDs, 10 INTs, plus 409 dashing yards and two scores. He averaged 16.0 fantasy factors per recreation. With an improved teaching employees, added playmakers and an upgraded offensive line, Maye is positioned to take a step ahead in 2025. See Week 1 rankings. — Moody

Betting nugget: That is the primary time in 17 video games that the Patriots (minus-2.5) are usually not underdogs, breaking the longest lively streak within the NFL. Learn extra. — ESPN Analysis

Maldonado's choose: Raiders 23, Patriots 20
Moody's choose: Patriots 17, Raiders 13
Walder's choose: Raiders 26, Patriots 24
FPI prediction: NE, 53.1% (by a median of 0.9 factors)

Matchup must-reads: Diggs prepared for Patriots' opener after 2024 ACL tear … Can Pete Carroll actually win straight away with the Raiders?

1 p.m. ET | CBS | Matchup ranking: 30.1/100
ESPN BET: ARI -6.5 (43.5 O/U)

What we're listening to on the Cardinals: So many questions are surrounding WR Marvin Harrison Jr. as he prepares for his second season. Particularly: Will he make the 12 months 2 bounce? One factor he gained from his first season that would contribute to his progress in 2025 is his expertise. “I knew it was a protracted season, however you do not know till you play it,” he stated. Harrison has been getting extra work executed on his physique to ensure he is as prepared as doable late within the season. — Josh Weinfuss

What we're listening to on the Saints: Saints nickel CB Alontae Taylor returned to observe Wednesday after lacking a number of weeks with a groin harm. Taylor stated he was forward of schedule in his rehab for a “irritating” harm, and he needed to shake the rust off in his first observe again. However total, he is feeling enthused in regards to the season. “I received a reasonably good chip on my shoulder going into this 12 months. So much to show, however I am prepared for it and excited,” he stated. — Katherine Terrell

Stat to know: The Saints have received a franchise-record six straight season openers (longest lively streak in NFL). No NFC group has had an extended such streak for the reason that 1984-92 Bears (9). — ESPN Analysis

Daring prediction: Saints QB Spencer Rattler will throw a number of interceptions. I count on the Saints to fall behind, and after they do, Rattler will take some dangers. Add in a 20% off-target fee and minus-10% completion proportion over expectation final season, and I count on a few these balls might land within the arms of Cardinals defenders. — Walder

Accidents: Cardinals | Saints

Fantasy nugget: James Conner completed final season with a career-high 1,094 dashing yards and completed because the RB11 in fantasy. The Saints' protection allowed the third-most dashing yards per recreation in 2024, whereas Arizona ranked eleventh in dashing makes an attempt. Conner is in line for an enormous recreation. See Week 1 rankings. — Moody

Betting nugget: Harrison went underneath receiving yards props in 12 of 17 video games final season (O/U 59.5 receiving yards for Week 1). Learn extra. — ESPN Analysis

Maldonado's choose: Cardinals 27, Saints 13
Moody's choose: Cardinals 27, Saints 16
Walder's choose: Cardinals 30, Saints 14
FPI prediction: ARI, 59% (by a median of three.8 factors)

Matchup must-reads: McBride seems to be to construct on 100-catch season … How Hurricane Katrina impacted two Saints coaches 20 years in the past … Cardinals imagine offensive continuity will make large influence

1 p.m. ET | Fox | Matchup ranking: 29.9/100
ESPN BET: JAX -3.5 (46.5 O/U)

What we're listening to on the Panthers: The Panthers have been the worst within the NFL at pressuring the passer final season, and disrupting Jags QB Trevor Lawrence will probably be key. Keep watch over a participant chances are you'll by no means have heard of in Carolina edge rusher Thomas Incoom. Fellow edge rusher D.J. Wonnum referred to him as a “lightning bolt.” Particular groups coach Tracy Smith says he “leads the nation in want-to.” Defensive coordinator Ejiro Evero referred to as him a “Tasmanian satan.” Keep tuned. — David Newton

What we're listening to on the Jaguars: The Jaguars need new coach Liam Coen to have the identical form of influence on their run recreation this season that he did in Tampa Bay in 2024, when the Bucs completed fourth in yards per recreation a season after ending final. The Panthers are opponent to begin towards as a result of they completed final in run protection in 2024 (179.8 yards per recreation). With two new starters in the midst of the OL (C Robert Hainsey and G Patrick Mekari) and skilled RBs Travis Etienne Jr. and Tank Bigsby, Coen is assured the run recreation will probably be higher, however there's nonetheless some uncertainty. “You will have a confidence and perception, however you are unsure what that would really appear like,” he stated. — Michael DiRocco

Stat to know: The Jaguars have suffered six straight losses in September (the longest lively streak within the NFL and one shy of tying their second-longest streak in franchise historical past). — ESPN Analysis

Daring prediction: Jaguars WR/CB Travis Hunter is not going to enable a reception as the closest defender to WR Tetairoa McMillan. It stays to be seen how usually the 2 will probably be matched up (and, I suppose, how a lot Hunter performs on protection), however I will again the No. 2 choose over the No. 8 choose after they do sq. off. — Walder

Accidents: Panthers | Jaguars

Fantasy nugget: McMillan enters Week 1 because the Panthers' No. 1 receiver with Adam Thielen traded and Jalen Coker (quad) sidelined. The rookie attracts a good matchup towards a Jaguars protection that allowed the fourth-most fantasy factors to receivers in 2024. See Week 1 rankings. — Moody

Betting nugget: The Panthers have ATS losses in every of their previous three Week 1 video games, tied for the longest lively streak within the NFL (Bengals). Learn extra. — ESPN Analysis

Maldonado's choose: Jaguars 24, Panthers 20
Moody's choose: Jaguars 26, Panthers 23
Walder's choose: Jaguars 20, Panthers 13
FPI prediction: JAX, 59.4% (by a median of three.9 factors)

Matchup must-reads: What Thielen's exit means for Younger, WRs … How Coen is managing Lawrence, Hunter

4:05 p.m. ET | Fox | Matchup ranking: 51.5/100
ESPN BET: SF -2.5 (43.5 O/U)

What we're listening to on the 49ers: For the primary time for the reason that 2020 season, the 49ers didn't play a single postseason recreation, which suggests a longer-than-usual period of time earlier than attending to play one other recreation that counts. “Whenever you're used to creating these deep runs after which getting off in [early] January, it looks like eternity,” LT Trent Williams stated. G Dominick Puni stated the Niners had a “tough” style of their mouths that lasted all offseason. The sense from the Niners' locker room is that they are desirous to get again on the sector and erase the exhausting emotions of final 12 months's 6-11 end. That they get to do it towards a division rival on the highway with a virtually totally wholesome roster solely provides to it. — Nick Wagoner

What we're listening to on the Seahawks: QB Sam Darnold's debut is the massive story of this recreation from Seattle's perspective, however there is a juicy matchup on the opposite aspect of the ball, the place playcalling head coaches Kyle Shanahan and Mike Macdonald will sq. off as soon as once more. Shanahan's offense received the higher of Macdonald's protection within the first assembly final season, a 36-24 49ers win in October. The Seahawks' 20-17 win 5 weeks later kicked off their defensive turnaround, with Seattle ending the season ninth in factors allowed. There's loads of optimism about that unit's capacity to take the following step in 2025 with so many key gamers again within the fold, and the opener towards Shanahan will probably be an early measuring stick. “He does an excellent job of preserving you off-balance,” Macdonald stated of his 49ers counterpart. “They deploy their folks totally different than some other group. That is one thing that is a focus of the way you concentrate on them.” — Brady Henderson

Stat to know: Though the Seahawks received 5 of their previous six season openers, they have been 3-6 at dwelling in 2024. — ESPN Analysis

Daring prediction: Seahawks RBs Zach Charbonnet and Kenneth Walker III will mix for 150-plus dashing yards. Seattle is hoping it has a brand new and improved floor recreation underneath offensive coordinator Klint Kubiak, and we might see it as early as Week 1. — Walder

Accidents: 49ers | Seahawks

Fantasy nugget: Receiver Ricky Pearsall is about to be a key contributor in Week 1. The 49ers are with out Brandon Aiyuk (knee) and Jauan Jennings continues to be getting back from a calf harm. In his 2024 debut stretch (Weeks 7-10), Pearsall averaged 17.4 fantasy factors per recreation and completed the season with back-to-back 15-plus-point video games. He ought to see heavy targets alongside TE George Kittle. See Week 1 rankings. — Moody

Betting nugget: The 49ers have ATS losses in every of their previous 5 highway video games, tied for the longest lively streak within the NFL (Browns and Giants). Learn extra. — ESPN Analysis

Maldonado's choose: 49ers 27, Seahawks 17
Moody's choose: 49ers 27, Seahawks 23
Walder's choose: Seahawks 24, 49ers 23
FPI prediction: SF, 54.1% (by a median of 1.7 factors)

Matchup must-reads: 49ers' Pearsall prepared for 2025 season, one 12 months post-shooting … How Darnold's one 12 months with 49ers ready him for Seahawks

4:05 p.m. ET | Fox | Matchup ranking: 40.2/100
ESPN BET: DEN -8.5 (42.5 O/U)

What we're listening to on the Titans: All eyes will probably be on QB Cam Ward making his debut, and rightfully so. However do not underestimate the dashing assault with Tony Pollard, who's coming off profession highs in makes an attempt (260) and yards (1,079), going towards a Broncos run protection that allowed 94 dashing yards per recreation final season, rating third within the NFL. Coach Brian Callahan stated the Titans will lean on the run recreation, however in addition they “simply want [Ward] to play good soccer and want the fellows round him to play properly for him.” — Turron Davenport

What we're listening to on the Broncos: As expectations and optimism swirled across the Broncos' protection all through the offseason — “we need to be the perfect protection within the league,” is how deal with D.J. Jones has put it — coordinator Vance Joseph has stated it may be thought-about among the many league's finest if it finds consistency and avoids “awkward performs” on Sunday. Ward would be the first rookie QB the Broncos have confronted within the season opener for the reason that AFL-NFL merger in 1970, and his improvisational abilities — even in his first NFL begin — would be the first take a look at for that protection. Search for the Broncos to attempt to hold Ward hemmed in as they attempt to squeeze the rookie off his first reads. — Jeff Legwold

Stat to know: Quarterbacks drafted No. 1 within the widespread draft period (since 1967) have a 4-15-1 report of their season opener as a rookie; Ward will probably be hoping so as to add to that win column. — ESPN Analysis

Daring prediction: Broncos CB Pat Surtain II will report an interception. Ward is really being thrown into the deep finish right here, going through the ferocious Broncos protection in his first NFL recreation — so we will not blame him an excessive amount of when he throws a choose to the reigning Defensive Participant of the 12 months. — Walder

Accidents: Titans | Broncos

Fantasy nugget: Bo Nix completed 2024 as QB7, rising as a prime fantasy choice because of his dual-threat capacity and improved accuracy late within the season. He opens 2025 towards a Titans protection that allowed the sixth-most dashing yards and third-most dashing TDs to QBs. Along with his dashing upside and prime receiver Courtland Sutton, Nix has a powerful Week 1 outlook. Offseason additions make him much more deadly, even towards a protection that allowed the fewest passing yards final season. See Week 1 rankings. — Moody

Betting nugget: Nix went over completions props in 12 of 17 video games final season. Learn extra. — ESPN Analysis

Maldonado's choose: Broncos 23, Titans 16
Moody's choose: Broncos 35, Titans 13
Walder's choose: Broncos 23, Titans 10
FPI prediction: DEN, 69.8% (by a median of seven.9 factors)

Matchup must-reads: Ridley: Suspension made me ‘mentally stronger' … Three components that may decide success for Nix

4:25 p.m. ET | CBS | Matchup ranking: 76/100
ESPN BET: GB -1.5 (47.5 O/U)

What we're listening to on the Lions: Kelvin Sheppard is “completely” excited. The Lions' new defensive coordinator will probably be making his debut alongside new offensive coordinator John Morton. However the focus in Detroit could be very a lot the Lions versus the Packers — neither Sheppard nor Morton is making this recreation about himself and each are preserving the group on the forefront. When requested about his mindset getting into the sport, “I am very anxious, however not nervous. It is a large distinction,” Sheppard stated on Thursday. Sheppard and Morton really feel ready because the Lions will attempt to set the tone for his or her season in Week 1 at Lambeau Subject. — Eric Woodyard

What we're listening to on the Packers: Micah Parsons' influence on the sector may not present up instantly. In spite of everything, he missed your complete preseason in Dallas and now has to be taught a brand new protection in Inexperienced Bay. However that does not imply he hasn't already made an influence within the locker room. “Personally it makes me need to do my half, do my job even higher,” LT Rasheed Walker stated. “I am actually trying ahead to competing in observe realizing that I'll get higher going towards extra competitors and, shoot, I really feel prefer it makes me and the group extra hungry for that Tremendous Bowl.” — Rob Demovsky

Stat to know: Jordan Love has seven consecutive video games with out an interception, which is the third-longest streak by a Packers QB behind eight- and nine-game stretches from Aaron Rodgers. — ESPN Analysis

Daring prediction: Lions CB D.J. Reed will enable 30 or fewer yards as the closest defender, per NFL Subsequent Gen Stats. Reed, who signed as a free agent this offseason, has been one of the crucial constantly strong cornerbacks within the league just lately. He has recorded better-than-average yards per protection snap allowed in 4 consecutive seasons, per NFL Subsequent Gen Stats. — Walder

Accidents: Lions | Packers

Fantasy nugget: Jared Goff opens Week 1 in Inexperienced Bay with out former offensive coordinator Ben Johnson, going through a powerful protection that allowed the sixth-fewest fantasy factors to QBs final season. Lambeau has been tough for him just lately, as Goff has averaged simply 206 passing yards per recreation in his previous 4 outings there, with a number of video games with lower than 14 fantasy factors. With a brand new OC and Parsons becoming a member of the Packers' go rush, it is smart to look into different quarterback choices. See Week 1 rankings. — Moody

Betting nugget: The Lions are 12-4 ATS towards the Packers since 2017, which is their second-best report towards any opponent over that span, minimal 4 conferences (5-1 versus Arizona). Learn extra. — ESPN Analysis

Maldonado's choose: Lions 27, Packers 23
Moody's choose: Packers 28, Lions 24
Walder's choose: Packers 24, Lions 17
FPI prediction: DET, 50.9% (by a median of 0.4 factors)

Matchup must-reads: Lions seeking to set tone towards Packers, Parsons … Parsons ‘ramping up,' says it is Packers' name on enjoying

4:25 p.m. ET | CBS | Matchup ranking: 58.7/100
ESPN BET: LAR -3.5 (43.5 O/U)

What we're listening to on the Texans: Coach DeMeco Ryans stated the quiet half out loud involving his offensive line, which is totally revamped and can embody rookie LT Aireontae Ersery. “Each offensive strains are going to should play properly and whoever wins that battle, I feel, will in the end determine the sport,” Ryans stated. — DJ Bien-Aime

What we're listening to on the Rams: Regardless of coping with an aggravated disk in his again, QB Matthew Stafford stated he will not be occupied with that when he is on the sector. “Clearly, would love to remain as clear as doable, however I am not pondering twice about that in any respect,” Stafford stated. “I am on the market able to go play.” Stafford and the Rams are going through a Texans protection that had success whereas pressuring quarterbacks final season, rating first in completion proportion allowed and tied for fourth in sacks. In accordance with ESPN Analysis, Stafford ranked seventeenth in completion proportion underneath strain in 2024. — Sarah Barshop

Stat to know: Stafford has began his group's season opener in all 16 seasons he has performed. — ESPN Analysis

Daring prediction: Rams WR Puka Nacua will report 100-plus receiving yards. Nacua had an absurd 3.7 yards per route run final season, and I count on him to hit the bottom working in 2025. — Walder

Accidents: Texans | Rams

Fantasy nugget: Nick Chubb would be the Texans' beginning RB to start the season with Joe Mixon (ankle) on injured reserve. Nonetheless, he'll share carries with Dameon Pierce and Woody Marks. Chubb averaged simply 3.3 yards per carry in eight video games with the Browns final season after getting back from a devastating knee harm that restricted him to 2 appearances in 2023. The larger concern for the working recreation is Houston's offensive line, which ranked thirty first in run block win fee final season and will battle once more regardless of offseason adjustments. See Week 1 rankings. — Moody

Betting nugget: The Texans are 11-6-1 ATS as highway underdogs since 2022, tied for fifth-best cowl proportion within the NFL. Learn extra. — ESPN Analysis

Maldonado's choose: Rams 24, Texans 20
Moody's choose: Rams 34, Texans 26
Walder's choose: Rams 27, Texans 20
FPI prediction: LAR, 53.7% (by a median of 1.8 factors)

Matchup must-reads: Why the Texans house owners really feel Houston is ‘fairly shut' … Stafford: Deal with Texans, not on ailing again

8:20 p.m. ET | NBC | Matchup ranking: 81.9/100
ESPN BET: BAL -1.5 (50.5 O/U)

What we're listening to on the Ravens: When QB Lamar Jackson was requested in regards to the largest key to beating the Payments, he rapidly stated: “Do not flip the ball over.” The Ravens have talked all offseason about their three turnovers — the “self-inflicted” errors — that led to a 27-25 divisional spherical loss to Buffalo final season. Since 2022, the Ravens are 1-6 when Jackson turns the ball over a number of occasions, together with that postseason loss in Buffalo. — Jamison Hensley

What we're listening to on the Payments: A banged-up Payments secondary is about to face fairly the problem to begin the season in Jackson, with each beginning CBs Christian Benford and Tre'Davious White coping with groin accidents. White didn't observe on Wednesday or Thursday, whereas Benford is shifting in a constructive route, totally collaborating in Thursday's observe. White's availability is a critical query mark, and if he cannot go, the position will go to Ja'Marcus Ingram — who has performed a backup position for the Payments earlier than — or sixth-round choose rookie Dorian Robust. Defensive coordinator Bobby Babich stated that Robust's “enchancment over the previous two weeks has been unbelievable.” — Alaina Getzenberg

Stat to know: That is the primary time the highest two gamers in MVP voting from the prior season meet in a season opener (since a minimum of 1970), and the fifth time the MVP winners from the prior two seasons face one another in a season opener (additionally since 1970). — ESPN Analysis

Daring prediction: Ravens TE Mark Andrews catches a landing. Given how a lot decrease the stakes are, it will not fairly erase his dropped 2-point conversion within the divisional spherical towards Buffalo — however it's one thing. With Isaiah Doubtless's standing in query because of the fractured foot harm he suffered, Andrews must be in line for loads of snaps, too. — Walder

Accidents: Ravens | Payments

Fantasy nugget: Khalil Shakir had a profession season in 2024, main the Payments in targets, receptions and receiving yards. He additionally ranked inside the highest eight in yards from the slot, which is notable for the reason that Ravens' secondary allowed the sixth-most yards and ninth-most to fit receivers. Shakir ought to proceed to function a security valve for Allen. See Week 1 rankings. — Moody

Betting nugget: Jackson has the perfect win proportion and canopy proportion as an underdog within the Tremendous Bowl period. Learn extra. — ESPN Analysis

Maldonado's choose: Payments 27, Ravens 24
Moody's choose: Ravens 23, Payments 20
Walder's choose: Ravens 31, Payments 27
FPI prediction: BUF, 51.1% (by a median of 0 factors)

Matchup must-reads: Andrews embraces contemporary begin after playoff drops

Monday, 8:15 p.m. ET | ESPN | Matchup ranking: 55.3/100
ESPN BET: MIN -1.5 (43.5 O/U)

What we're listening to on the Vikings: With nationwide consideration understandably targeted on the debut of QB J.J. McCarthy, it has been straightforward to overlook the Vikings' rising emphasis on a working recreation that may pair Aaron Jones Sr. and Jordan Mason with a rebuilt offensive line. Within the three earlier seasons underneath coach Kevin O'Connell, the Vikings have had solely two video games of 30 or extra carries by working backs. That determine is now a baseline expectation towards the Bears and different early-season opponents as McCarthy grows into the job. In planning for the run recreation this summer season, O'Connell stated he requested himself one query above all else: “What permits us to play probably the most a number of method? As a result of that each one circles again to the No. 1 query of: What makes the quarterback's job simpler?” — Kevin Seifert

What we're listening to on the Bears: CB Jaylon Johnson returned to observe for the primary time since sustaining what he categorized as a “fairly unhealthy” groin harm whereas engaged on his releases throughout offseason coaching. Though his availability for the Vikings recreation is in query as a result of he has been sidelined since July, Johnson is raring to be again on the sector in a task that may enable him to showcase his finest towards Minnesota's finest. “I am extra enticed to go towards [WR Justin Jefferson] than the quarterback, per se,” Johnson stated. “However hopefully there are some passes which might be left inside for me to have the ability to intercept on sure coverages or regardless of the case could also be. We're trying ahead to disrupting him rather a lot.” — Courtney Cronin

Stat to know: The Bears start their season by going through the Vikings in Week 1, then the Lions in Week 2. Based mostly on final season's win-loss data, that's the hardest two-game stretch by any group to start this season. — ESPN Analysis

Daring prediction: Vikings LB Blake Cashman will lead the NFL in tackles in Week 1. Cashman ranked fourth amongst linebackers in run cease win fee (44.3%) final season, and the Bears determine to deploy a run-heavy offense underneath new coach Ben Johnson. — Walder

Accidents: Vikings | Bears

Fantasy nugget: Receivers DJ Moore and Rome Odunze are arrange for sturdy fantasy outings towards the Vikings. Minnesota's protection allowed the second-most receiving yards and probably the most fantasy factors to outdoors receivers final season. Moore alone posted 42 fantasy factors towards them in 2024. With an improved offensive line and Johnson calling performs, each Moore and Odunze must be locked into lineups. See Week 1 rankings. — Moody

Betting nugget: Jefferson went over receiving yards props in 11 of 17 video games final season (O/U 78.5 yards in Week 1). Learn extra. — ESPN Analysis

Maldonado's choose: Bears 23, Vikings 20
Moody's choose: Bears 26, Vikings 20
Walder's choose: Bears 24, Vikings 21
FPI prediction: CHI, 51.5% (by a median of 0.6 factors)

Matchup must-reads: How the Vikings overhauled their roster forward of Week 1 … QB Williams has ‘unapologetic' strategy in 12 months 2