Week 6 of the NFL season will get underway with a matchup of NFC East rivals when Jalen Hurts and the Philadelphia Eagles go to Jaxson Dart and the New York Giants on Thursday evening.
The struggling Baltimore Ravens will attempt to get again on observe in Sunday's early window of video games, however they will face a troublesome check in opposition to the Los Angeles Rams.
In Sunday's late afternoon window, the Tampa Bay Buccaneers host the San Francisco 49ers in a matchup of 4-1 groups, and the day's slate concludes with the Kansas Metropolis Chiefs (-1.5) taking up the Detroit Lions.
Monday evening incorporates a doubleheader with the Chicago Bears visiting the Washington Commanders and the Buffalo Payments dealing with the Atlanta Falcons.
Eric Karabell, Pamela Maldonado, Matt Bowen, Eric Moody, Joe Fortenbaugh and Seth Walder appeared on the early Week 6 odds and recognized which of them are price leaping on now earlier than potential shifts later within the week.
Be aware: Odds at time of publication, courtesy of ESPN BET Sportsbook

Philadelphia Eagles at New York Giants complete UNDER 42 (-110)
Maldonado: This NFC East matchup profiles as a traditional divisional underneath. The Eagles lack explosiveness, counting on a run sport that is constructed on quantity fairly than chunk performs. The Giants wrestle to maintain drives, changing simply 32% of third downs. Each defenses are robust situationally, and each offenses function at a sluggish tempo, averaging over half-hour of possession per sport. With restricted vertical threats and inconsistent pink zone execution on either side, this initiatives as a sport outlined by sustained drives, stalled possessions and area targets, which factors to a complete that stays comfortably underneath the mark.
Final week: Giants-Saints underneath 42 (Saints received 26-14)

Los Angeles Rams at Baltimore Ravens complete OVER 45.5 (-110)
Karabell: The Ravens are lacking so many key gamers on protection that they've managed to allow 37 or extra factors in 4 of their 5 video games. Issues is not going to get higher in opposition to Matthew Stafford and the highest large receiver duo within the league (Puka Nacua and Davante Adams). Frankly, the Rams may rating 46 factors on their very own if the Ravens, in all probability led by backup QB Cooper Rush, may simply hold tempo a bit. As an instance that does not happen, however the Rams rating 40, the Ravens get on the board and this over hits.
Final week: Lions-Bengals over 49.5 (Lions received 37-24)
Tampa Bay Buccaneers to cowl -2.5 (-130)
vs. San Francisco 49ers
Bowen: I just like the Bucs at house versus a banged-up 49ers crew that has to make the journey to Tampa. With the extent of play we're seeing from quarterback Baker Mayfield, who's tied for third within the league with 10 landing throws, and a protection that holds a strain fee of 34.6%, the Bucs can cowl at house.
Final week: Chiefs -2.5 at Jaguars (TBD)
49ers to cowl +2.5 (+110)
at Buccaneers
Moody: The 49ers get a couple of further days to heal after their extra time win over the Rams final Thursday evening. San Francisco hopes to have Jauan Jennings and Ricky Pearsall again within the fold, however with Mac Jones underneath heart in opposition to Los Angeles, the offense confirmed it is in succesful fingers if he wants to start out once more rather than Brock Purdy. The Buccaneers are coming off a win over the Seattle Seahawks, however they're additionally coping with accidents. On condition that San Francisco has received 4 of its previous 5 conferences with Tampa Bay, it is onerous to not again the 49ers as underdogs.
Final week: Raiders-Colts over 47.5 (Colts received 40-6)
Pittsburgh Steelers to cowl -4.5 (-115)
vs. Cleveland Browns
Fortenbaugh: This guess is all in regards to the spot. Pittsburgh is at house and coming off a bye week, whereas Cleveland is touring again from London following Sunday's loss to the Minnesota Vikings. This may be probably the most favorable scheduling benefit for any crew on the 2025 NFL calendar.
Walder: I am proper there with Joe. That is the spot that instantly jumped out at me. I am removed from totally purchased in on Pittsburgh, however at house off a bye in opposition to a Browns crew getting back from London and beginning Dillon Gabriel in his second-ever begin (after he posted a 38.9 QBR in his debut)? That definitely feels prefer it must be price greater than 4.5 factors. FPI flippantly agrees with my (and Joe's) instinct, making the unfold Steelers by 5.2. Sure, the Browns could have a major pass-rushing edge over the Steelers' offensive line, however that must be considerably mitigated by the truth that Pittsburgh has the quickest time to launch within the league at 2.51 seconds. Plus, you already know who additionally has a line of defense with an edge over its opponent Sunday? The Steelers.
